Moreover, factors that facilitate permeation through vasculature are vascular endothelial growth factor (VEGF/VPG) [39, 40], nitric oxide [41, 42], bradykinin [43, 44], peroxynitrite (ONOO-), matrix metalloproteinases (MMPs) [45], prostaglandins (PGs) [46], and cytokines-like tumor. This evidence concerns the gene VEGFA and neoplasm.