The previous researches indicated a crucial role of CKS2 (cyclin‐dependent kinases regulatory subunit 2) in hepatocellular carcinoma and breast cancer; however, little is known about the molecular mechanism of CKS2 in the tumorigenesis and epithelial‐mesenchymal transition‐like (EMT) process in glioma. The gene discussed is CKS2; the disease is central nervous system cancer.