RBFOX3 and Alzheimer disease: The AD patient iNs exhibited well-developed and mature neuronal characteristics, but the number of TUJ1+/NeuN+ cells was slightly decreased in the AD patient iNs that expressed APOE ε4 at the amyloid-seeding stage, compared to the AD patient iNs without APOE ε4 expression, while no such difference was found when APOE ε4 was expressed at the amyloid progressive stage (Fig. 1f).