Since we were able to identify amyloid (6E10) oligomers at day 7 in AD patient iNs (Fig. 1b, c; Additional file 1: Fig. S1a-d), we conditionally overexpressed APOE ε4 with doxycycline from day 7 as the amyloid oligomer-seeding stage and day 14 as the amyloid-oligomer progressive stage after ABM induction (Fig. 1a). This evidence concerns the gene APOE and Alzheimer disease.