Thus, to support clinicians in better scheduling, and prevention of drug resistance increasement we performed PCR amplification, and sequencing to evaluate CAM-R related point mutations in 23S rRNA and rpl22 genes, and Realtime-PCR in the classification of total patients in the early stage of gastritis in Helicobacter pylori positive infected individuals, and Clarithromycin resistant strains infected patients based on cyp2c19 gene mapping. Here, RPL22 is linked to gastritis.