Specific to FOXC1, a GWAS study discovered a SNP at ~ 61.7 kb 5′ of FOXC1 (rs2745572[A]) that was significantly associated with primary open-angle glaucoma (POAG) and vertical cup-to-disk ratio, an important endophenotype for glaucoma [18, 19]. This evidence concerns the gene FOXC1 and glaucoma.