FOXC1 and open-angle glaucoma: Literature review additionally revealed a SNP, rs2745572[A], associated with primary open-angle glaucoma (POAG) and increased vertical cup-to-disk ratio (a glaucoma endophenotype) [18, 19], located in the intergenic region between FOXC1 and FOXF2 at ~ 61.7 kb upstream of FOXC1 and ~ 152.6 kb downstream of FOXF2. BLAST-based comparisons of the human intergenic sequence to corresponding genomic regions between zebrafish foxc1a/b and foxf2a/b failed to identify any conserved elements in these regions.