High intraocular pressure accompanied by an enlargement of the ocular globe (known as buphthalmos) is a common manifestation of congenital glaucoma [50], one of the developmental phenotypes associated with mutations in FOXC1. The mechanism of this disorder is not fully known; however, human studies identified developmental defects in the drainage structures of patients with congenital glaucoma caused by CYP1B1 mutations [51]. The gene discussed is FOXC1; the disease is congenital glaucoma.