HSPA8 is implicated in a signal transduction pathway in the abnormal proliferation of chronic myeloid leukemia (CML) cells, suggesting that the chaperone HSPA8 and CCND1 contribute to the abnormal behavior of CML cells and represent an interesting target for new therapies [41]. Here, HSPA8 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.