CCL2 and rheumatoid arthritis: Moreover, we found changes in the expression of cytokines and chemokines which are usually increased in this condition, such as C-C Motif Chemokine Ligand 2 (CCL2) and interleukin (IL)-18, or with anti-inflammatory effects as interleukin (IL)-2Receptor Antagonist (RA) and interleukin (IL)-1RA [20].