The two cases (2 and 5) with metastatic disease at diagnosis displayed a higher number of HGS enriched compared to the other cases, such as Epithelial_mesenchimal_transition, Interferon_alpha_response, Interferon_gamma_response, Inflammatory_response, Oxidative_phosphorilation, Apoptosis, Hyopoxia, KRAS_signaling_up, TGF_beta_signaling, TNFA_signaling_via_NFKB. Here, NFKB1 is linked to metastatic neoplasm.