HDAC6 and neurodegenerative disease: Based on these findings, the most promising yet sill experimental approaches to the treatment of neurodegenerative diseases comprise the induction of autophagy with compounds like rapamycin and lithium66,67, treatment with small molecules that induce stabilization of MTs like paclitaxel or epothilone B68 and, in more recent years, with compounds that induce MT-acetylation via e.g. deacetylase-inhibitors like trichostatin-A and HDAC6 inhibitors69,70.