BNIP3L and cancer: To assess the expression of Gp78 in multiple cancers, we used GEPIA-2 analysis to probe TCGA RNAseq data for mRNA expression of Gp78 and other ubiquitin ligases that induce mitophagy (PARK2, RNF185, MUL1, MARCH5, HUWE1, SIAH1) as well as the hypoxia-induced mitophagy proteins BNIP and NIX [59].