The close alignment of neuroradiological features between the tubulinopathies, PAFAH1B1(LIS1)-related lissencephaly, and the CAMSAP1-related neuronal migration disorder is consistent with a shared pathomolecular mechanism underlying these diseases and highlights the role of the minus end of the microtubule in neuronal migration disorders. The gene discussed is PAFAH1B1; the disease is tubulinopathy.