The close alignment of neuroradiological features between the tubulinopathies, PAFAH1B1(LIS1)-related lissencephaly, and the CAMSAP1-related neuronal migration disorder is consistent with a shared pathomolecular mechanism underlying these diseases and highlights the role of the minus end of the microtubule in neuronal migration disorders. Here, PAFAH1B1 is linked to lissencephaly spectrum disorders.