Additionally, and in agreement with a previous report (55), we also detected rare heterozygous mutations in some genes, including AP3B1, PRF1, LYST and DOCK8, that are associated with familial hemophagocytic lymphohistiocytosis in patients with MIS-C (Supplemental Data File 2). Here, PRF1 is linked to hereditary hemophagocytic lymphohistiocytosis.