Moreover, in mice either expressing an active form of Notch1 in Tregs (Foxp3EGFPCreR26N1c/+) or lacking NUMB expression in these cells (Foxp3EGFPCreNumbΔ/Δ), treatment with polyinosinic:polycytidylic acid (poly I:C) to simulate viral infection induced systemic inflammation. Here, NUMB is linked to viral infectious disease.