Importantly, dominant-negative loss-of-function mutations in NUMB and NUMBL found in patients with MIS-C resulted in increased Notch1 expression and Notch1 signaling, consistent with the pathogenic function of these mutations in this pathway in promoting MIS-C in the context of a systemic viral infection such as with SARS-CoV2. The gene discussed is NOTCH1; the disease is viral infectious disease.