By contrast, ectopic expression of EBF1 (Supplemental Figure 4, B and C), IRF4 (Supplemental Figure 4, D and E), or PAX5 (Supplemental Figure 4, F and G) in HEL or THP1 cells could not reprogram the AML cells nor activate expression of the other MCL lineage-survival TFs. The gene discussed is PAX5; the disease is acute myeloid leukemia.