Interestingly, although somatic gain-of-function hotspot FOXO1 mutations have not been found in MCL, our examination of human MCL cell lines found a frequent coexistence of high levels of FOXO1 protein expression with hyperactivated PI3K/AKT signaling (Supplemental Figure 5B), suggesting that FOXO1 protein stability and PI3K/AKT activity are likely uncoupled in MCL. The gene discussed is AKT1; the disease is mantle cell lymphoma.