Consistently, immunoblot and RT-qPCR analyses of the AML cell line THP1 revealed that enforced expression of FOXO3-1, but not the FOXO1r#1-3 variant, was able to robustly induce MCL lineage-survival TF expression in AML-line THP1 cells (Figure 5, F and G, and Supplemental Figure 6, F and G). This evidence concerns the gene TF and acute myeloid leukemia.