PLPP7 and Emery-Dreifuss muscular dystrophy: The altered splicing map for TMEM38A reveals that not only is its expression highly elevated in EDMD patients (log2FC = 2.9) but also that the protein-coding isoform displays a higher usage relative to abundance compared with the non-coding isoform (Fig. 5F) Many other notable mis-spliced genes are involved in myotube fusion such as the previously mentioned NID1 that is under spatial genome positioning control of NET39, another of the genome organizing NETs causative of EDMD.