Accordingly, we sought to search for commonly affected pathways from a much wider range of EDMD-linked genes including LMNA, EMD, FHL1, SUN1, SYNE1, PLPP7 and TMEM214 alleles on the expectation that, covering an even wider genetic and clinical spectrum, the most important pathways for EDMD pathophysiology would be highlighted. The gene discussed is FHL1; the disease is Emery-Dreifuss muscular dystrophy.