SYNE1 and Emery-Dreifuss muscular dystrophy: Roughly a fifth each of EDMD mutations occurs in LMNA and EMD while another 5–6% are collectively caused by four other widely expressed nuclear envelope proteins nesprin 1 (encoded by SYNE1), nesprin 2 (encoded by SYNE2), Sun1 (encoded by SUN1) and FHL1 (encoded by FHL1) (14,15,22–24)).