Accordingly, we sought to search for commonly affected pathways from a much wider range of EDMD-linked genes including LMNA, EMD, FHL1, SUN1, SYNE1, PLPP7 and TMEM214 alleles on the expectation that, covering an even wider genetic and clinical spectrum, the most important pathways for EDMD pathophysiology would be highlighted. This evidence concerns the gene LMNA and Emery-Dreifuss muscular dystrophy.