Extending previous reports [44], duodenal tissues of our CVID enteropathy patients displayed increased T-cell infiltration and a disturbed T-cell homeostasis, characterized by a significant decrease in TH17 and an expansion of TH1 cells, corroborated by a strong induction of IFN-γ on transcript and protein level within a total tissue of CVID VA patients. Here, IFNG is linked to common variable immunodeficiency.