In contrast to LACTB induction, the treatment of a panel of breast cancer cell lines (MCF7ras, HCC1806, Hs578t) with Actinomycin D resulted in PARP degradation and caspase cleavage in all or some of our tested cell lines (caspase 7, 8 9) confirming the onset of caspase-dependent apoptosis (Fig. 2D). The gene discussed is LACTB; the disease is breast cancer.