In this regard, LACTB was shown to mediate tumour suppression through PI3K/AKT/mTOR in colorectal cancer [7], inhibiting Hippo pathway in melanoma [8], modulating lipid metabolism in breast cancer and hepatocellular carcinoma [2, 6] and regulating autophagy in gastric cancer [4]. Here, LACTB is linked to hepatocellular carcinoma.