The risk for R1 resection was also higher for tumors with positive lymph node status (N1-3), OR = 1.580 (95% CI 0.894–2.791, p = 0.115). Regarding tumor biology, the risk for R1 resection was higher in hormone receptor negative tumors than in hormone receptor positive tumors, OR being 2.241 (95% CI 1.056–4.756, p = 0.036). This evidence concerns the gene NR4A1 and neoplasm.