PTEN and cancer: mTORC1 activation, such as in the context of oncogenic phosphoinositide 3-kinase (PI3K) mutation or PTEN deletion, can lead to ferroptosis resistance in cancer cells by activating SREBP1, which in turn upregulates stearoyl-CoA desaturase 1 (SCD1) to catalyze MUFA production (Yi et al., 2020).