Meanwhile, PRR11, EREG, ADM, and TGM2, which were overexpressed in the low AIDPS group, played a vital role in the proliferation, invasion, and metastasis of many tumors such as breast cancer, colorectal cancer, and PACA, and lead to their chemotherapy resistance and were potential targets for enhanced efficacy (Lee et al., 2020; Neufert et al., 2013;Aggarwal et al., 2012; Malkomes et al., 2021). The gene discussed is EREG; the disease is permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome.