It was demonstrated that PEDF significantly inhibited lung cancer cell proliferation and viability by suppressing autophagy through the downregulation of the adenosine 5′-monophosphate-activated protein kinase (AMPK)/Unc-51 like autophagy-activated kinase 1 (ULK1) signaling pathway in NSCLC cells. The gene discussed is SERPINF1; the disease is lung cancer.