CD14 and systemic sclerosis: On the other hand, the set of 27 interacting genes observed in CD14+ monocytes showed enrichment in tyrosine kinase activity (Supplementary Table 15), which plays an important role in fibrosis and has been related with SSc pathogenesis, making tyrosine kinase inhibitors one of the most promising antifibrotic therapies for SSc and other fibrotic diseases (42).