VeCadIfnar1_KO mice exhibited increased tumor burden (Figure 4D) and mortality rates (Figure 4—figure supplement 2D) when compared to NaCl-treated Ifnar1fl/fl mice, suggesting that hepatic endothelial Ifnar1 signaling exerts significant anti-tumor activity even in the context of physiologic endogenous intrahepatic levels of type I interferons. The gene discussed is IFNAR1; the disease is neoplasm.