IFNA1 and neoplasm: The results also suggest that this effect may be dependent on the capacity of IFN-sensitive HECs and LSECs to foster antitumor immunity, especially tumor-specific effector CD8+ T cell responses that are well-known to control tumor growth in vivo in different experimental settings (Dobrzanski et al., 2000; Katlinski et al., 2017; Klebanoff et al., 2005; Yu et al., 2019).