It is also interesting to note that IFNα-stimulated LSECs promote microvascular alterations like those typifying pathological conditions (e.g. initial hepatic capillarization and liver fibrosis Pandey et al., 2020; Wohlfeil et al., 2019) associated with impaired immune cell extravasation and reduced immune surveillance (Guidotti et al., 2015) and reduction of hepatic metastases from solid tumors including CRCs (Wohlfeil et al., 2019). Here, IFNA1 is linked to Hepatic fibrosis.