Furthermore, histological analysis of hepatic CRC lesions from NaCl- and IFNα-treated VeCadIfnar1_KO mice euthanized at day 21 after MC38 intramesenteric injection indicated that these tumors resembled NaCl-treated Ifnar1fl/fl lesions, showing signs of angiogenesis (as denoted by CD34 positivity) and similar content of F4/80+ macrophages and CD3+ T cells within the intrahepatic CRC foci (Figure 4—figure supplement 3A, B). Here, IFNA1 is linked to colorectal carcinoma.