Indeed, IFNα stimulated LSEC-governed changes hampering CRC extravasation including the modification of the sinusoidal GCX that, by increasing its thickness and modifying its chemical composition, recapitulated conditions known to negatively regulate the trans-endothelial migration of tumor cells in other settings (Glinskii et al., 2005; Mitchell and King, 2014; Offeddu et al., 2021; Wilkinson et al., 2020). This evidence concerns the gene IFNA1 and colorectal carcinoma.