MRI analysis at day 21 after CRC challenge revealed that, in comparison with liver metastases observed in NaCl-treated controls, the lesions produced by MC38- or MC38Ifnar1_KO cells in IFNα-treated mice were similarly reduced in number and size (Figure 4A and C–D) and this resulted in comparable mouse survival rates (Figure 4E) in the absence of apparent myelotoxicity (Figure 4—figure supplement 2A). The gene discussed is IFNA1; the disease is colorectal carcinoma.