IFNA1 and neoplasm: Additionally, other cell types within the hepatic niche could further amplify this IFNα-initiated cascade, as it has been shown that dendritic cells releasing IFNα also reduce liver metastatic colonization by CRC cells (Toyoshima et al., 2019) and that this cytokine properly polarizes the tumor microenvironment (Catarinella et al., 2016; De Palma et al., 2008).