In this context, Fay et al. have shown cell-aggregation of mRNA transcript of C9orf72 gene in ALS affected neurons, proving that nucleic acids can form aggregates.57 These results make the C9Orf72 gene an incredibly appealing target to underpin the mechanism of action of nucleic acid in the context of pathological aggregates. This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.