Instead, cold TME C1 contained the highest percentage of Community 6 (Supplementary Fig. 9d) that was characterized by CAIX+ tumor cells in close contact with MC2 and Collagen+ stromal cells; and C2 was mostly dominated by Community 4 (Supplementary Fig. 9e) enriched for networks of Vimentin+ stromal cells and HLA-DR−VEGF+ myeloid cells MC2. The gene discussed is MC5R; the disease is neoplasm.