Additionally, several immunosuppressive cells, including Treg, Breg, MDSC, and Kupffer cells, inhibit immune cell activity by producing cytokines such as TGF-β and IL-10 and inducing key factors in CD8+ T and NK cell depletion, leading to immune escape of HBV and HCC tumor cell [34–37]. This evidence concerns the gene CD8A and hepatocellular carcinoma.