However, the expression levels of IL-6 (31.30 ± 7.59%), TP53 (32.97 ± 5.35%), and MAPK1 (31.73 ± 2.95%) in the VIN+HPD group were lower than those of the VIN group (P < 0.05). The gene discussed is MAPK1; the disease is vulvar intraepithelial neoplasia.