A large epidemiological study has shown that the incidence of women with PCOS is 5.6% in the Chinese Han population.[10] Endocrine imbalances include elevated total testosterone (TT) levels, high luteinizing hormone/follicle stimulating hormone ratio (LH:FSH) along with metabolic derangements.[2] Previous theories suggest that defects in the H-P-O axis lead to increased LH secretion. This evidence concerns the gene PLOD1 and polycystic ovary syndrome.