CXCL2 and cancer: CXCL2, a small secreted member of the CXC chemokine family, affects cell proliferation and apoptosis in hepatocellular carcinoma.[6] In addition, Zhang et al has suggested that CXCL2 is a prognostic biomarker in bladder cancer.[11] In STAD, CXCL2 and CXCL1 are found to be associated with cancer chemoresistance and metastasis.[12] These results suggest that CXCL2 may also play a critical role in cancer.