In our study, enrichment analysis and cancer-related pathway of CXCL2 in STAD suggested that CXCL2 is mainly involved in leukocyte activation, immune response, immunological synapse, cytokine-cytokine receptor interaction, Th1 and Th2 cell differentiation, NF-kappa B signaling pathway, TNF signaling pathway, IL-17 signaling pathway, nucleotide excision repair, apoptosis pathway, EMT pathway, RAS/MAPK pathway, cell cycle pathway, DNA damage response pathway, and hormone AR pathway. The gene discussed is CXCL2; the disease is gastric adenocarcinoma.