High ALMS1-IT1 expression predicted a poorer overall-survival (P = .005) and poorer progression-free interval (PFI) (P = .012), and ALMS1-IT1 expression was independently correlated with PFI in COAD patients (hazard ratio (HR) :1.468; 95% CI: 1.029–2.093; P =.034) (HR: 1.468; 95% CI: 1.029–2.093; P = .034). The gene discussed is ALMS1; the disease is colon adenocarcinoma.