For example, among the phytomedicinal components of XBJ, Radix Salviae Miltiorrhizae attenuates endotoxin-induced HMGB1 release from macrophages and monocyte cultures, which is a late mediator of lethal sepsis.[26] In the LPS-induced RAW 264.7 cell model, the main components of Radix Paeoniae Rubra, paeoniflorin and paeoniflorin, were found to have anti-inflammatory activity.[27]. This evidence concerns the gene HMGB1 and Sepsis.