IL1β is a proinflammatory cytokine, that can continuously promote the release of endogenous arachidonic acid, resulting in the persistent hypersensitivity of mechanical nociceptors, and the increase in inflammatory cytokines is involved in the process of vascular injury caused by BD.[19] MMP-9 plays an important role in immune inflammation, cell migration, proliferation, and apoptosis. This evidence concerns the gene MMP9 and Behcet disease.