What’s important, the high mRNA expression of SMC2, SMC3, and SMC4 were found to be associated with worse PFS, these findings suggested that individual SMC family members, especially SMC2, SMC3, and SMC4, are potential relative factors of prognosis in HCC and forecast that the use of SMC inhibitor targeting SMC2, SMC3, and SMC4 may be a practical strategy for HCC therapy. Here, SMC4 is linked to hepatocellular carcinoma.