SMC4 and central nervous system cancer: SMC4, located in 3q25.33, was found highly expressed in HCC patients.[11] In addition, high expression level of SMC4 could be an independent factor to predict poor survival in colorectal cancer,[13,38] and is also related to the aggressiveness of glioma.[39] In the present study, it was found that the expression of SMC2, SMC3 and SMC4 in HCC tissues were significantly higher than in normal liver tissues.