SMC4, located in 3q25.33, was found highly expressed in HCC patients.[11] In addition, high expression level of SMC4 could be an independent factor to predict poor survival in colorectal cancer,[13,38] and is also related to the aggressiveness of glioma.[39] In the present study, it was found that the expression of SMC2, SMC3 and SMC4 in HCC tissues were significantly higher than in normal liver tissues. Here, SMC3 is linked to hepatocellular carcinoma.