It was found that 4 SMC members (SMC2, SMC3, SMC4, SMC6) and 1 clinical feature (stage) were closely associated with poor outcome of HCC patients (hazard ratio [HR] for SMC2: 1.137 [1.051–1.230]; HR for SMC3: 1.041 [1.009–1.075]; HR for SMC4: 1.094 [1.038–1.152]; SMC6: 1.119 [1.001–1.250]); HR for stage: 1.679 (1.368–2.061) (Table 1). This evidence concerns the gene SMC6 and hepatocellular carcinoma.