Production of the pyrogen IL-1β begins with the first wave of infected cells and TNF began at the stage of skin infection responsible for fever, muscle pain, and anorexia.[23] In addition, type 1 interferon contributes to various clinical symptoms, the range of which is clearly delineated during the administration of exogenous interferon in a therapeutic setting: fatigue, headache, chills, and fever.[24] In this study, there were 229 cases of dengue fever and 2 cases of severe dengue fever. This evidence concerns the gene IL1B and skin infection.