ACE and Fabry disease: The clinical diagnosis of FD is mainly based on detailed family history, abnormal enzyme and LysoGb3 levels, typical renal histopathological features, and genetic testing.[11] Electron microscopy examination of renal biopsy samples and observed zebra bodies is important for diagnosing FD and eliminating other primary and secondary renal diseases.[6,12] Angiotensin-converting enzyme inhibitor or angiotensin receptor blocker (ARB) is individually used for the nonspecific adjunctive treatment of FD.