The results showed that NPM2 protein level expression (negative vs. positive) was independently negatively correlated with the following two clinicopathological factors: CC score [odds ratio (OR) = 0.332, 95% CI: 0.112–0.984, P = 0.047] and vascular tumor emboli (OR = 0.095, 95% CI = 0.012–0.764, P = 0.027) (Table 2). This evidence concerns the gene NPM2 and vascular neoplasm.