Univariate survival analysis showed that the prognosis of MPM was related to the following eight clinicopathological factors: NPM2 protein expression (P = 0.046), KPS (P = 0.006), increased preoperative tumor markers (P = 0.001), ascites (P = 0.044), red blood cell infusion (P = 0.044), Ki-67 (P = 0.002), vascular tumor emboli (P = 0.046), and SAEs (P = 0.002). The gene discussed is NPM2; the disease is neoplasm.