TCGA database showed that RBCK1 was moderately elevated in human breast cancers (Fold change = 1.36), while RBCK1 was also elevated all different subtypes compared with normal breast tissue (Luminal type, FC = 1.43; HER2 positive, FC = 1.16; TNBC, FC = 1.07) (Fig. 3A,B). The gene discussed is ERBB2; the disease is breast carcinoma.