The missense variant p.Cys325Gly in APOH was also associated with increased risk of atrial fibrillation (P = 3.5 × 10−9, OR = 1.12, ncases = 96,018), heart failure (P = 2.4 × 10−9, OR = 1.12, ncases = 99,214) and higher levels of lipoprotein (a) (Lp(a); P = 2.2 × 10−56, effect = 0.10 s.d). Here, APOH is linked to heart failure.