In addition, it has been recently reported that TBK1 is inhibited in tumor cells bearing p53 mutants,71 suggesting that p53 mutants may impair the intracellular STING signaling pathway; however, intercellular STING signal transduction via R-EVs is unlikely to be affected, as the activated STING in EVPs derived from p53-mutant MDA-MB-231 cells treated with diABZI was functional (Supplementary information, Fig. S1g). This evidence concerns the gene STING1 and neoplasm.