TBK1 and cancer: It has been reported that STING can be activated in cancer cells treated by chemoradiotherapy,35,36 and we also found that the STING-TBK1 pathway was activated in NCI-H1975 cells treated with various chemotherapeutic drugs, including cisplatin (DDP), adriamycin (ADR), rucaparib (Ruc), hydroxyurea (HU) and 5-fluorouracil (5-FU), as well as irradiation (IR) (Supplementary information, Fig. S2a, b).