STING1 and neoplasm: To investigate whether STING is present on EVs, we collected EVs and particles (EVPs, 100 K pellet)30,31 from various tumor cells treated with or without STING agonists.32,33 Interestingly, STING agonist treatment effectively activated the STING pathway in these cell lines (Supplementary information, Fig. S1a–c) and promoted activated STING to be packaged into EVPs.