IFNB1 and cancer: Consistently, the localization of endogenous STING in MVB-like structures was clearly observed in NCI-H1975 cells stably expressing RAB22AWT or RAB22AQ64L in response to Ruc treatment (Fig. 3m), suggesting that cancer patients bearing high RAB22A levels in tumors may benefit from chemoradiotherapy, as the production of IFNβ was induced in THP-1 cells incubated with EVPs derived from NCI-H1975 cells treated with Ruc or IR (Fig. 2g, h).