As shown in Supplementary Fig. 20, in the VNP-GD/EI-NP@Gel group, there were more Rhodamine B-labeled GD proteins distributed in the tumor than that in the GD/EI-NP@Gel group which could be attributed to the strong motility and hypoxia tropism of VNP improving the tumoral delivery and penetration of GD proteins. This evidence concerns the gene PAEP and neoplasm.