GSDME and neoplasm: Specifically, Granzyme A released from cytotoxic lymphocytes cleaves Gasdermin B (GSDMB) to trigger pyroptosis in target tumor cells, while cytotoxic lymphocytes secreted Granzyme B or chemotherapy-induced activated caspase 3 cleaves Gasdermin E (GSDME) to trigger tumor pyroptosis5–7.