HCRT and Cataplexy: We found that orexin-caspase-3 mice occurred cataplexy with sudden muscle weakness and REM-like sleep during wakefulness (Fig. 5b and Supplementary Video S1) and exhibited a high amount of cataplexy (F(1,72) = 104.7, P < 0.001, ANOVA; Fig. 5c, left).