BAK1 and colorectal cancer: To evaluate whether sensitivity to AZ’1569 correlated with expression levels of proapoptotic and antiapoptotic BCL-2 family members or DR_MOMP stress dose, we initially determined the basal absolute BCL-2 proteins profiles (BAK, BAX, BCL-2, Bcl-xL, MCL1) in our KRASG12CMT colorectal cancer cells (Supplementary Fig. S3B).