It may also be consistent with what is observed in human populations, in which APOL1-G1 associates with more significant albuminuria and kidney disease compared with APOL1-G2 in homozygous individuals [65–67], and with HIV-associated nephropathy and hypertension-associated end stage kidney disease in heterozygous individuals [57, 68]. The gene discussed is APOL1; the disease is Hypertension.