In accordance with our S-pseudotyped lentivirus infection data (Fig 2B), co-expression of CD169 and ACE2 led to an increase in SARS-CoV-2 infection compared to ACE2-expressing cells, with higher levels and slightly earlier production of dsRNA and SARS-CoV-2 N (compare Fig 3C and 3D). This evidence concerns the gene SIGLEC1 and lentivirus infection.