Interestingly, a recent study suggests that CD169 also recognizes gangliosides, such as GM1 and GM3, incorporated in SARS-CoV-2 particle membrane, and can mediate trans infection of ACE2+ cells [14], similar to our previously reported findings on GM3-dependent CD169-mediated trans infection of HIV-1 [39,43]. The gene discussed is SIGLEC1; the disease is infection.