Knock-down of RIG-I, MDA-5, UNC93B1, MAVS or STING in THP1/CD169 macrophages did not impact infection efficiency of SARS-CoV-2, as shown by RT-qPCR analysis of viral gRNA and sgRNAs in each cell line (Fig 8C and 8D). Here, SIGLEC1 is linked to infection.