Interestingly, expression of both CD169 and ACE2 in macrophages led to enhanced kinetics and magnitude of infection, reflecting an entry-enhancing effect of CD169 even in the context of ACE2-mediated infection, though the mechanism of enhanced kinetics of SARS-CoV-2 replication in CD169+/ACE2+ macrophages remains unclear. Here, SIGLEC1 is linked to infection.