Similar to the findings in THP1/PMA macrophages, exogenous expression of CD169 in HEK293T cells resulted in significant enhancement of SARS-CoV-2 S pseudotyped lentivirus entry and infection (S4A Fig), but viral protein expression was not observed in HEK293T/CD169 cells infected with recombinant SARS-CoV-2 expressing NeonGreen (SARS-CoV-2-mNG) (S4B Fig). Here, SIGLEC1 is linked to infection.