Notably, NEAT1 was upregulated upon ectopic co-expression of ICP22 and ICP27 (2.2-fold, p<10−11) and in ΔICP22 (2.1-fold, p<10−4) and ΔICP27 (4.9-fold, p<10−12) infection, but not upon expression of either ICP22 or ICP27 alone. This evidence concerns the gene NEAT1 and infection.