TLR7 and infection: However, we found that the differences in the percentage of CD11b+Ly6G+Ly6C−/low PMN-MDSCs or CD11b+Ly6G−Ly6Chigh M-MDSCs between WT and TLR7-KO mouse lung were not obvious after infection (Fig 4A), which indicated that TLR7 knockout did not affect the subsets of S. japonicum infection-induced lung MDSCs.