Since AT1R signaling is involved in aneurysm growth in MFS mice, but we do not observe reduced aneurysm growth with C1-INH Cetor®, it may be concluded that the observed AT1R signaling in MFS mice is not dependent on renin but rather mediated by a local cue such as stretch-induced activation of AT1R (49). The gene discussed is REN; the disease is aneurysm.