Expression levels of IL1β, IL6, IL17α, and TNF-sf11 were significantly lower in P2×r5−/− mice compared to WT mice, and this reduction led to decreased periodontitis (gum disease) and decreased alveolar bone loss compared with WT mice, when challenged by LPS from Porphyromonas gingivalis [64]. The gene discussed is TNFSF11; the disease is periodontitis.