TNFRSF8 and mycosis fungoides: Whilst some studies suggest that, in MF patients, the presence of DUSP22-R might help differentiate concurrent primary cutaneous CD30-positive LPD from large cell transformation, others cast doubt on the utility of this, DUSP22-R being found in two of eleven cases of large cell transformation of mycosis fungoides (LCT-MF) in one study [57, 59].