SCN1A and epilepsy: Indeed, Scn1a, the gene that encodes NaV1.1, is referred to as a ‘super culprit’ gene, with over 1000 associated mutations that lead to abnormal brain function, resulting in brain disorders such as epilepsy and migraine, as well as neurodivergent phenotypes, such as autism spectrum disorder (Ding et al., 2021; Lossin, 2009).