Several studies provide evidence that CD169+ subcapsular marginal zone and sinus MP in the spleen and LN, respectively, may produce type I IFN in response to viral infections (VSV, Vaccinia, MCMV) (Gui et al., 2019; Brault et al., 2018; Gaidt et al., 2017). This evidence concerns the gene SIGLEC1 and viral infectious disease.