SIGLEC1 and malaria: While we establish the existence of a functional interaction between these MP and the pDC in the BM of malaria-infected mice, further investigations will be needed to determine (1) the nature of the STING-dependent signals derived from CD169+ MP that allow pDC to achieve type I IFN-producing capacity and egress the BM to the blood and (2) whether this interaction is direct or not, and may also take place in other tissues and infections or autoimmune diseases.